Abstract Background Innovation in healthcare is said to be notoriously difficult to achieve and sustain yet simultaneously the health service is under intense pressure to innovate given the ever increasing demands placed upon it.Whilst many studies have looked at diffusion of innovation from an organisational perspective, few have sought to underst
Neither sulfoxaflor, Crithidia bombi, nor their combination impact bumble bee colony development or field bean pollination
Abstract Many pollinators, including bumble bees, are in decline.Such declines are known to be driven by a Western Boots number of interacting factors.Decreases in bee populations may also negatively impact the key ecosystem service, pollination, that they provide.Pesticides and parasites are often cited as two of the drivers of bee declines, parti
Are pvcrt-o and pvmdr1 Gene Mutations Associated with Plasmodium vivax Chloroquine-Resistant Parasites?
(1) Background: Malaria remains a significant global public health issue.Since parasites quickly became resistant to most of the available antimalarial drugs, treatment effectiveness must be Osram QTi Dimmable Ballasts constantly monitored.In Brazil, up to 10% of cases of vivax malaria resistant to chloroquine (CQ) have been registered.Unlike P.fal
The hypoxia-driven crosstalk between tumor and tumor-associated macrophages: mechanisms and clinical treatment strategies
Abstract Given that hypoxia is a persistent physiological feature of many different solid tumors and a key driver for cancer malignancy, it is thought to be a major target in cancer treatment recently.Tumor-associated macrophages (TAMs) are the most abundant immune cells in the tumor microenvironment (TME), which have a large impact on tumor develo
Details of the Horse Bridle from the Burial of the Sarmatian Horseman from Kovalevka Kurgan Cemetery
Introduction.The article publishes and analyzes the materials founded by the kurgan research near the village of Kovalevka in the southern part of the Volga-Don interfluve.Kurgan No.13 is part of a kurgan cemetery, where the burials look relatively simultaneous and can be interpreted as a cemetery of nomadic migrants, settled in this territory in t