Neither sulfoxaflor, Crithidia bombi, nor their combination impact bumble bee colony development or field bean pollination

Abstract Many pollinators, including bumble bees, are in decline.Such declines are known to be driven by a Western Boots number of interacting factors.Decreases in bee populations may also negatively impact the key ecosystem service, pollination, that they provide.Pesticides and parasites are often cited as two of the drivers of bee declines, parti

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The hypoxia-driven crosstalk between tumor and tumor-associated macrophages: mechanisms and clinical treatment strategies

Abstract Given that hypoxia is a persistent physiological feature of many different solid tumors and a key driver for cancer malignancy, it is thought to be a major target in cancer treatment recently.Tumor-associated macrophages (TAMs) are the most abundant immune cells in the tumor microenvironment (TME), which have a large impact on tumor develo

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